Conflicting evidence has been found regarding the association between high tobacco consumption and body weight among smokers. In the second examination, individuals are invited from the same. Healthy lifestyles reduce supar and mortality in a danish. Ushapedrelationshipofhdlandrisk ofinfectiousdisease. Fh initiative headlining the congress was the launch of the eas familial hypercholesterolaemia studies collaboration fhsc, a consortium of major fh registries across europe, asiapacific, africa and south america, led by professor kausik ray imperial college, london. Faculty of health and medical sciences, university of copenhagen, copenhagen, denmark. Exploring causal associations between alcohol and coronary. Jul 29, 20 we included individuals from the copenhagen general population study, a prospective population study.
The participants completed a questionnaire on health and lifestyle, were examined physically, had blood drawn for dna extraction, were tested for presence of chek21100delc using. The authors thank the staff and participants of the copenhagen general population study and the copenhagen city heart study, and the participants of the metaanalyses of glucose and insulinrelated traits consortium magic, the ckdgen consortium, the uk biobank, and the cardiogramplusc4d consortium for their generous participation. Genomewide association and transcriptome studies identify target genes. The advantage of this approach in contrast to nested casecontrol studies is that the copenhagen general population study will contain an ever increasing amount of information on all participants allowing for detailed studies of risk factor interactions and in substrata of the general population. Arterial and venous thrombosis by high platelet count and. Copenhagen university hospital, clinical biochemistry, herlev, denmark. Furthermore, diseasefree participants of the copenhagen general population study are very well suited to act as controls in casecontrol studies, where other research groups can provide cases. The relationship between volumetric thoracic bone mineral. Increased risk for other cancers in addition to breast.
The authors have reported that they have no relationships relevant to the contents of this paper to disclose. Accaha guidelines superior to esceas guidelines for. The copenhagen general population study atherosclerosis. Major longlasting european studies of the general population. In this study the population sample was also a stratified, family cluster design. The participants completed a questionnaire before attending a physical examination including collection of whole blood for dna. The population was grouped according to number of traditional risk factors and heart score was used to assess the risk of event for those with no cac, those with only cms 0 and those with both as and cms 0. Mendelian randomisation studies have not shown a clear causal effect of high plasma glucose on the risk of alzheimers disease. The copenhagen general population study n 56 960 is a prospective study initiated in 2003,20 and the copenhagen city heart study n 9041 is a prospective study initiated in 1976. Below, the same research outputs are grouped by subject. Hover over the donut graph to view the fc output for each subject. The copenhagen general population study cgps is a danish contemporary population based cohort study initiated in 2003 with ongoing enrollment.
The cgps is an ongoing prospective cohort study of the danish general population. New findings from an analysis of 98,097 subjects from the copenhagen city heart study and the copenhagen general population study link lpa with risk for heart failure. Methods participants from the copenhagen general population study underwent multidetector computed tomography. A mendelian randomisation design was used with data. Briefly, 61,301 individuals from a general population, aged 30 to 60 years and living in the southwestern part of copenhagen were randomly selected to participate in the study. Seroepidemiology of pertussis in a crosssectional study. Dec 15, 2016 the copenhagen city heart study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population. Jan 16, 2018 observational study of actual ascvd events during 10 years, followed by a modeling study to estimate the effectiveness of different guidelines. Prognosis of asymptomatic and symptomatic, undiagnosed copd. Wheezing was selfreported, and asthma was ascertained through selfreport, hospital contacts with. The highdensity lipoproteinadjusted score model worsens scorebased risk classification in a contemporary population of 30,824.
Combined value of exhaled nitric oxide and blood eosinophils. This study aims to investigate infancy predictors of psychopathology in the second year of life. Characteristics and outcomes of chronic obstructive pulmonary. We studied participants in the copenhagen general population study, an ongoing cohort study initiated in 2003. The copenhagen general population study the primary study cohort was comprised of 97 166 individuals from the prospective copenhagen general population study with baseline measurements of hdl cholesterol. Obese individuals experience wheezing without asthma but not. But perhaps, a headtohead comparison of remnant cholesterol with ldl cholesterol can be reported on in a followup publication, similar to what we have reported previously for individuals in the general population 15 and in patients with ischemic heart disease. The copenhagen general population study, denmark institution. In the eclipse evaluation of copd longitudinally to identify predictive surrogate endpoints study cohort, only 37% of the patients with copd had persistently increased blood eosinophils at or above 2%. The current study population consisted of participants in a large population based study, inter99, which is reported in detail elsewhere 25, 39, 40. The aim of this study was to assess the potential relationship between volumetric thoracic bone mineral density and coronary calcification in a large population of men and women. Pdf predictors 010 months of psychopathology at age.
We identified individuals with copd spirometrically. Comparison of major guidelines for statin use in primary. Copenhagen general population study 2003 to 2006 examination and copenhagen city heart study 2001 to 2003 examination7 recruited participants randomly from the general population of copenhagen, denmark. General population study cgps 20032007 exami nation 7 and the copenhagen city heart study. Majority of neversmokers with airflow limitation do not have. Impact of glucose level on micro and macrovascular. Methods we genotyped 85 437 individuals aged 20100 years from the copenhagen general population study for fto rs9939609, mc4r rs177823, tmem18 rs6548238 gnpda2 rs10938397 and bdnf rs10767664. We included individuals from the copenhagen general population study, a prospective population study. View the article pdf and any associated supplements and figures for a period of 48 hours.
The copenhagen general population study is supported by the copenhagen county foundation and herlev and gentofte hospital, copenhagen university hospital, denmark. The initial sample has been reinvited up to four times and supplemented by younger individuals. Setting copenhagen city heart study, copenhagen general population study, and copenhagen ischemic heart disease study. Combined effect of pnpla3, tm6sf2, and hsd17b variants. Coronary artery calcium assessed with calibrated mass. Increased risk for other cancers in addition to breast cancer. The copenhagen general population study abstract send to citation mgr. Participation rates in general population studies in europe vary from 10% 15 to.
The copenhagen general population study herlevosterbroundersogelsen 2008. Participants 95 766 white participants of danish descent from three cohorts, with median followup times. The first 5592 included copenhagen general population study participants had lipoproteina total mass measured using a sensitive immunoturbidimetric assay from diasys diasys, diagnostic systems, holzheim, germany and the following participants in the copenhagen general population. Increasedriskforothercancersinadditiontobreastcancer for. Risk of venous thromboembolism and myocardial infarction. The copenhagen city heart study is a prospective cardiovascular study of the danish general population initiated in 1976. What is the abbreviation for copenhagen general population study.
Nationwide studies of idiopathic interstitial pneumonia and chronic obstructive pulmonary disease in the danish population. Oct 09, 2015 the copenhagen city heart study, also known as osterbroundersogelsen, is a large prospective cardiovascular population study of 20,000 women and men that was launched in 1975 by dr peter schnohr and dr gorm jensen together with statistician jorgen nyboe and prof. Risk factors for chronic cough in the general population have not been described systematically. Krogfelt1 1department of microbiology and infection control, statens serum institut, copenhagen denmark 2epidemiology research, statens serum institut, copenhagen denmark 3department of microbiology.
Seroepidemiology of pertussis in a crosssectional study of an adult general population in denmark p. Major longlasting european studies of the general population this online supplement includes short summaries of largescale studies of the general population on the epidemiology of respiratory diseases and allergy that have been in progress for about 30 years or more and are still active. Genetically low vitamin d concentrations and increased. In the present study we pooled data from two similar but independent studies. Bg medicine and copenhagen general population study. In the copenhagen general population study, the jak2 v617f mutation was detected by a pcrbased taqman screening assay identifying the 1% with the highest signal, these were subsequently tested with a highly sensitive realtime qpcr assay with a limit of detection of 0. The table to the right includes counts of all research outputs for the copenhagen general population study published between 1 december 2018 30 november 2019 which are tracked by the nature index. Characteristics and outcomes of chronic obstructive. We recorded blood eosinophils at baseline and future copd exacerbations longitudinally, defined as moderate shortcourse treatment with systemic corticosteroids or severe hospitalization. We tested the hypothesis that individuals from the general population with high platelet count or high hematocrit have high risk of arterial and venous thrombosis.
Lipoproteina and ischemic heart disease a causal association. Cgps abbreviation stands for copenhagen general population study. Prevalence, characteristics, and prognosis of early. Platelet count and blood hematocrit were measured at. Eligibility and preventive potential for new evidence. The highdensity lipoproteinadjusted score model worsens. Total mortality by transferrin saturation levels oxford academic. Elevated lipoproteina and risk of ischemic stroke jacc. Risk factors for chronic cough among 14,669 individuals from. The copenhagen general population study cgps is an ongoing prospective cohort study of the danish general population. So far, the main focus of studies using the copenhagen general population study has been genetic epidemiology, but we have also been focusing on. All participants answered similar questionnaires, which. Outcomes consequent to early copd for interventional studies. Combined effect of pnpla3, tm6sf2, and hsd17b variants on.
Among 81,668 individuals in the copenhagen general population study, we examined 7,225 with copd based on spirometry. Obese individuals experience wheezing without asthma but not asthma without wheezing. New analysis from copenhagen general population study reaffirms. The copenhagen city heart study, also known as osterbroundersogelsen, is a large prospective cardiovascular population study of 20,000 women and men that was launched in 1975 by dr peter schnohr and dr gorm jensen together with statistician jorgen nyboe and prof. Patients and methods we examined 86,975 individuals from the copenhagen general population study, recruited from 2003 through 2010. The cchs provided the general population sample from denmark. It was initiated in 2003 and recruitment is ongoing. Analyses were performed in the copenhagen general population study with a mean sd of 7. We tested the hypothesis that high plasma glucose caused by genetic variation has a causal effect on the risk of unspecified dementia, alzheimers disease and vascular dementia in the general population. All individuals in denmark are assigned a unique identification number at birthimmigration that is recorded in the national danish civil registration system. Among 81,668 individuals from the copenhagen general population study, we examined 7,225 with copd based on spirometry. High risk of fatty liver disease amplifies the alanine. Methods study design and participants we included 5578 individuals aged 20100 years from the second examination of the copenhagen general population study cgps, a populationbased prospective cohort study initiated in april 2014 with ongoing enrolment.
Obesity as a causal risk factor for aortic valve stenosis. Methods study design and participants we included 5578 individuals aged 20100 years from the second examination of the copenhagen general population study cgps, a population based prospective cohort study initiated in april 2014 with ongoing enrolment. Jan 22, 2019 the current study population consisted of participants in a large population based study, inter99, which is reported in detail elsewhere 25, 39, 40. Majority of neversmokers with airflow limitation do not. Objective to study regulatory problems rps of feeding, sleeping and excessive crying in infancy, and explore the influence of maternal mental health problems and parentchild relationship problems. The copenhagen city heart study is a prospective study of the copenhagen general population initiated in 1976. Obese individuals experience wheezing without asthma but. Icosapent ethyl for the prevention of cardiovascular events.
The copenhagen general population study documented that in a general population context among individuals with copd, blood eosinophil levels above 340 cells. Copenhagen general population study the british journal of. Rennard was particularly interested in estimating the sample size required for an intervention trial in individuals with early copd based on the outcomes used in our. Bg medicine today announced that it has entered into a research collaboration agreement with the copenhagen general population study with the goals to discover and validate novel cardiovascular biomarkers, including those. The copenhagen general population study, herlev and gentofte hospital, herlev, denmark. We included 5578 individuals aged 20100 years from the second examination of the copenhagen general population study cgps, a population based prospective cohort study initiated in april 2014 with ongoing enrolment. We identified and ranked chronic cough risk factors at the individual and community level using data from 14,669 individuals from the copenhagen general population study. Leukotriene c4 synthase and risk of cardiovascular. The copenhagen general population study was initiated in 2003 with ongoing enrollment. Participants were selected randomly from the national civil registration system to represent the danish population aged 20100 years.
Methods the study included 49,699 individuals from the copenhagen general population study and 10,8 individuals from the copenhagen city heart study with measurements of plasma lipoproteina, lpa kringleiv type 2 number of repeats, and lpa rs10455872. Furthermore, our study indicates the need for a multifaceted. A total of 58527 individuals from the cgps had baseline measurements of lpa. The copenhagen city heart study osterbroundersogelsen. The copenhagen city heart study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population. In this questionnaire we will ask you to answer some questions about your health and lifestyle. Design, setting, and participants this population based contemporary cohort study included 6292 patients with known ischemic heart disease ihd and 2277 with a previous myocardial infarction mi enrolled between november 2003 and february 2015. We tested the hypothesis that high tobacco consumption is causally associated with low body weight. The study includes questionnaires, clinical assessment and biomarkers. Future longitudinal studies should focus on possible risk factors for airflow limitation in this population. We recorded blood eosinophils at baseline and future copd exacerbations longitudinally, defined as moderate shortcourse treatment of systemic corticosteroids or severe hospitalization.
Problems of feeding, sleeping and excessive crying in infancy. A random general population sample of 210 children from the copenhagen child birth cohort ccc 2000 was investigated by data from national danish registers and data collected prospectively from. Study design, participation and characteristics of the. The first crosssectional survey on the general population sample of urban and suburban residents of pisa pi1 was performed in 19851988. A random general population sample of 210 children from the copenhagen child birth cohort ccc 2000 was investigated by data from national danish registers and data collected prospectively from birth in a general child health surveillance programme. Prevalence, characteristics, and prognosis of early chronic. We observed that individuals with chronic respiratory symptoms and normal spirometry had an increased risk of hospitalisations and death due to respiratory disease 1. Remnant cholesterol and triglyceriderich lipoproteins in. Original article majority of neversmokers with air. Design and setting data were collected in the general child health surveillance delivered to infant families by community health nurses chns. In the copenhagen general population study, with 81,668 individuals, the corresponding value was 63 %. Prevalence, characteristics, and prognosis of early chronic obstructive pulmonary disease.
News from the european atherosclerosis society congress. The copenhagen city heart study, bispebjerg and frederiksberg hospital, copenhagen, denmark. Hospital10 the copenhagen general population study, herlev hospital. Epidemiological studies of mental health problems in the first years of life are few. Participants completed a selfadministered questionnaire concerning. Remnant cholesterol and myocardial infarction in normal weight, overweight, and obese individuals from.
Participants n 2985 from the copenhagen general population study were evaluated for cac using both conventional as and cms. We prospectively followed 108 521 individuals from the copenhagen general population study for a median of 8 years. Nordestgaard 2,3,4, marianne benn 2,3,4, luisa zuccolo 1, anne tybjaerghansen 2,3,5, and george davey smith 1. In this prospective cohort study, we analysed data from 95 288 individuals aged 20100 years from the copenhagen general population study. The two sister studies in the copenhagen area include the copenhagen city heart study and. Danish population study offers opportunity for discovery of blood biomarkers in individuals who suffer a heart attack without prior history of cardiovascular disease.
In the present study, we compared the clinical performance of these two risk assessment models and evaluated the incremental predictive value of hdl cholesterol in an independent and contemporary european population, the copenhagen general population study cgps. Nov 18, 2014 objective to test the hypothesis that genetically low 25hydroxyvitamin d concentrations are associated with increased mortality. Blood eosinophils and exacerbations in chronic obstructive. Pdf the copenhagen city heart study osterbroundersogelsen.
1103 200 996 567 1067 679 1383 922 1215 895 172 1426 1442 661 1389 560 509 586 421 826 320 1331 356 187 167 1068 1360 1215 278 536 1261 743 221 296 882 247 277 770